Thesis Abstract and Dissertation Abstracts

The objective of the present study was to evaluate the in-vitro anti- cancer effects of ethanolic extract of seed of Myristica fragrans (Houtt) against seven human cancer cell lines.Cancer cell line of central nervous system, and Colon cancer cell line (Colon 502713, Colo 205), Liver cancer cell line (Hep-2), Lung cancer cell line (A-549), Ovary cancer cell line OVCAR-5, Prostrate cancer cell line (PC-5). The SRB assay was used to test cytotoxic activity all the cell line. The activity was evaluated at 100 µg / ml concentration of test material. OVCAR -5 (Ovary) cell line showed highest cytotoxic activity 97 %. Growth inhibition of colon 502713 and PC-5 (Prostrate) cell was 86 %. SF-295(CNS) and colo 205 showed 73 % growth inhibition while Hep-2 (Liver) showed 72 %. A-549 (Lung) showed no significant activity (50 %). Our results indicate that the plant has a promising anti-cancer activity. The ethanolic extract of plant showed highest anti-cancer activity against OVCAR-5. Further investigation for active compound present in Myristica fragrans required for cancer management and for the development of new anti- cancer drugs.

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Submission Details: Thesis Abstract submitted by sweta prakash from India on 20-May-2012 12:26.
Abstract has been viewed 3402 times (since 7 Mar 2010).

sweta prakash Contact Details: Email: ekta-prakash1@hotmail.com Phone: 9451058024