Thesis Abstract and Dissertation Abstracts
Action Of Benzodiazepines On The Chloride Channel Of Different Subtypes Of Gabaa Receptors: Has Molecular Biology Facilitated The Understanding Of The Receptor Pharmacology Or Vice Versa?
Abstract Category: Science
Course / Degree: Pharmacology
Institution / University: University of East London, United Kingdom
Published in: 2011
GABAA receptor shows pentameric structure, belongs to the superfamily of ‘‘cys–cys loop’’ ligand gated ion channel. It is activated by the neutral amino acid GABA (γ-Amino butyric acid ) is the key inhibitory neurotransmitter present in the mammalian central nervous system (CNS), is extensively distributed in the neurons of the adult brain. GABAA receptor consist of 5 different subunits and have different binding sites for benzodiazepines, barbiturates, alcohol , steroids and some centrally acting drugs. The biochemical and pharmacological studies described the heterogeneity of GABAA receptor, but the findings of receptor cloning techniques unfolded the receptor subunit complex and their subtypes. This allowed the pharmacologists to establish the functional role of different subtypes in combination with gene manipulation techniques. This study discusses the contribution of molecular biology and receptor pharmacology in revealing the complexity of GABAA receptor subtypes and development of subtypes selective compounds. It also highlights the strengths and weakness of both approaches.
Dissertation Keywords/Search Tags:
GABAA, BENZODIAZEPINES, MOLECULAR BIOLOGY,PHARMACOLOGY
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Submission Details: Dissertation Abstract submitted by Rafi Uszama Mohammed from United Kingdom on 01-Sep-2011 20:11.
Abstract has been viewed 3154 times (since 7 Mar 2010).
Rafi Uszama Mohammed Contact Details: Email: rafeezama@yahoo.com
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