Thesis Abstract and Dissertation Abstracts
Expression of chemokines and chemokine receptors in human breast cancer cells under inflammatory stimuli. Implications for cancer metastasis.
Abstract Category: Science
Course / Degree: Philosofical Doctorade/PhD2
Institution / University: Universidad Nacional Autonoma de Mexico, Mexico
Published in: 2009
Interactions between tumour cells and microenvironments may affect their growth and metastasis formation. Several studies have demonstrated the important role of cellular mediators in the progression of breast cancer cells. The effect of pro-inflammatory cytokines, such as IL-1, IL-6, TNF-α and IFN-g on the regulation of expression of chemokine receptors and autocrine-paracrine positive feed-back loops for releasing of inflammatory factors are the key steps in regulating trafficking and metastasis. Indeed, breast cancer cells express chemokine receptors in a non-random manner, and these observations pointed to several chemokine/ receptor pairs that control cell–cell migration.
This thesis gives some light to understand the interplay between tumour cells, stroma/inflammatory cells and inflammatory cytokines/chemokines and let us to propose additional levels of cross-talk between tumour cells and inflammatory mediators which are taking place in the surrounding microenvironment. In addition, a better understanding of the role played by the inflammatory components in breast cancer progression may also lead the way to the find of new therapeutic targets.
Thesis Keywords/Search Tags:
Breast cancer, chemokines, inflammation, metastasis
This Thesis Abstract may be cited as follows:
Valdivia-Silva, J.E. 2009. Expression of chemokines and chemokine receptors in human breast cancer cells under inflammatory stimuli. Implications for cancer metastasis. PhD Thesis. Universidad Nacional Autonoma de Mexico, Mexico. pp. 137
Submission Details: Thesis Abstract submitted by Julio Valdivia-Silva from United States on 09-Dec-2010 00:11.
Abstract has been viewed 3168 times (since 7 Mar 2010).
Julio Valdivia-Silva Contact Details: Email: julvalsil@gmail.com Phone: +1-408-480-7533
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